Recommendation Statement

• The U.S. Preventive Services Task Force (USPSTF) makes recommendations about preventive care services for patients without recognized signs or symptoms of the target condition.
• It bases its recommendations on a systematic review of the evidence of the benefits and harms and an assessment of the net benefit of the service.
• The USPSTF recognizes that clinical or policy decisions involve more considerations than this body of evidence alone. Clinicians and policymakers should understand the evidence but individualize decisionmaking to the specific patient or situation.

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Importance. Good evidence indicates that although stroke is a leading cause of death and disability in the United States, a relatively small proportion of all disabling, unheralded strokes is due to CAS.

Detection. The most feasible screening test for severe CAS (for example, 60% to 99% stenosis) is duplex ultrasonography. Good evidence indicates that this test has moderate sensitivity and specificity and yields many false-positive results. A positive result on duplex ultrasonography is often confirmed by digital subtraction angiography, which is more accurate but can cause serious adverse events. Noninvasive confirmatory tests, such as magnetic resonance angiography, involve some inaccuracy. Given these facts, some people with false-positive test results may receive unnecessary invasive carotid endarterectomy surgery.

Benefits of Detection and Early Intervention. Good evidence indicates that in selected, high-risk trial participants with asymptomatic severe CAS, carotid endarterectomy by selected surgeons reduces the 5-year absolute incidence of all strokes or perioperative death by approximately 5%. These benefits would be less among asymptomatic people in the general population. For the general primary care population, the benefits are judged to be no greater than small.

Harms of Detection and Early Intervention. Good evidence indicates that both the testing strategy and the treatment with carotid endarterectomy can cause harms. A testing strategy that includes angiography will itself cause some strokes. A testing strategy that does not include angiography will cause some strokes by leading to carotid endarterectomy in people who do not have severe CAS. In excellent centers, carotid endarterectomy is associated with a 30-day stroke or mortality rate of about 3%; some areas have higher rates. These harms are judged to be no less than small.

USPSTF Assessment. The USPSTF concludes that for individuals with asymptomatic CAS there is moderate certainty that the benefits of screening do not outweigh the harms ("D" recommendation).

Patient Population

This recommendation applies to adults without neurologic signs or symptoms, including a history of transient ischemic attacks or stroke. If otherwise eligible, an individual who has a carotid-area transient ischemic attack should be evaluated promptly for consideration of carotid endarterectomy.

Risk Assessment

In a setting of excellent surgical care and low complication rates, screening may benefit patients who have a very high risk for stroke. It is not clear, however, how to identify people whose risk for stroke is high enough to justify screening, yet do not also have a high risk for surgical complications. The major risk factors for CAS include older age, male sex, hypertension, smoking, hypercholesterolemia, and heart disease.

Screening Tests

Available screening and confirmatory tests (duplex ultrasonography, digital subtraction angiography, and magnetic resonance angiography) all have imperfect sensitivity and appreciable harms. Therefore, screening could lead to non-indicated surgeries that result in serious harms, including death, stroke, and myocardial infarction, in some patients.

Useful Resources

In other recommendations, the USPSTF notes that adults should be screened for hypertension, hyperlipidemia, and smoking. In addition, clinicians should discuss aspirin chemoprevention for those who have an increased risk for cardiovascular disease. The evidence and recommendations on these conditions from the USPSTF are available on the Agency for Healthcare Research and Quality Web site at http://www.uspreventiveservicestaskforce.org.

Burden of Disease

The contribution of CAS 60% to 99% to the morbidity and mortality associated with stroke, or to the natural progression of asymptomatic CAS in the general population, is not precisely known.^1,2 Based on population-based studies and the accuracy of carotid duplex, the estimated prevalence of CAS 60% to 99% in the general population over age 65 years is about 1%. Studies have found that CAS is more prevalent in older adults, smokers, those with hypertension, and those with heart disease. Research has not found any single risk factor or clinically useful risk stratification tool that can reliably and accurately distinguish people who have clinically important CAS from those who do not.

Scope of Review

In 1996, the USPSTF concluded that evidence was insufficient to recommend for or against screening of asymptomatic patients for CAS by using a physical examination or carotid ultrasonography. To update its recommendation, the USPSTF examined high-quality evidence on the natural history of CAS, systematic reviews of the accuracy of screening tests, and randomized, controlled trials (RCTs) of the benefits of treatment of CAS with carotid endarterectomy. Because the magnitude of potential surgical harms is such an important consideration in the treatment of CAS, the USPSTF conducted a systematic review of this issue.

Accuracy of Screening Tests

Two meta-analyses provide information on the accuracy of carotid duplex ultrasonography in detecting clinically important stenosis. Recent systematic reviews of studies about the accuracy of carotid duplex ultrasonography, by using digital subtraction angiography as the reference standard, estimated the sensitivity to be 86% to 90% and the specificity to be 87% to 94% for detecting CAS greater than 70%.^3,4 The estimated sensitivity and specificity of carotid duplex ultrasonography to detect CAS of 60% or more are approximately 94% and 92%, respectively.³ The reliability of carotid duplex ultrasonography is not established.³ One meta-analysis noted that the measurement properties used among various ultrasonography laboratories varied greatly and to a clinically important degree.³ In 1996, the USPSTF reviewed the evidence for screening for bruits on physical examination and found that the test had poor reliability and poor sensitivity.⁵

Effectiveness of Early Detection and Treatment

Two good-quality RCTs, the ACAS (Asymptomatic Carotid Atherosclerosis Study) and the ACST (Asymptomatic Carotid Surgery Trial), compared carotid endarterectomy plus medical management to medical management alone in participants without symptoms attributable to the studied artery.^6,7 The ACAS projected a 5-year rate of ipsilateral stroke and any perioperative stroke or death that was lower in the carotid endarterectomy group than in the medical group: 5.1% versus 11.0% (relative risk reduction, 0.53 [95% CI, 0.22% to 0.72%]). If strokes associated with angiography were included, the difference between the groups was 5.6% versus 11.0%, or an absolute difference of 5.4 percentage points over 5 years. The estimated relative risk reduction was greater for men than for women (0.66 and 0.17, respectively). The ACST projected a lower 5-year rate of any stroke or perioperative death in the carotid endarterectomy group than in the medical group: 6.4% versus 11.8% (absolute difference, 5.4 percentage points [CI 2.96% to 7.75%]). About half of the strokes prevented by carotid endarterectomy were disabling. The treatment groups did not statistically significantly differ in all-cause mortality in either of the studies.

The RCTs on carotid endarterectomy for asymptomatic CAS have important limitations in terms of their generalizability to the primary care population. The RCTs included highly selected participants and surgeons. The 30-day perioperative results of the RCTs were reported as a combined outcome that did not include acute nonfatal myocardial infarction, which is an important complication. The medical treatment arm in the RCTs was poorly defined, was not kept constant over the course of the study, and would not have included treatments that are now considered to be optimal medical management, including aggressive management of blood pressure and lipids.

Potential Harms of Screening and Treatment

Tests done to confirm carotid duplex ultrasonography have associated harms. If all positive tests are followed by digital subtraction angiography, about 1% of people would experience a nonfatal stroke as a result of the angiogram. If positive tests are not followed by confirmatory angiography but rather by magnetic resonance angiography or computed tomography angiography—tests with less than 100% accuracy—some patients will have unnecessary carotid endarterectomy, with consequent harms in the absence of proven benefit.

Fourteen good- or fair-quality observational studies that evaluated carotid endarterectomy complications in patients with asymptomatic CAS were identified for USPSTF review. Overall, 30-day perioperative stroke or death rates in asymptomatic patients ranged from 1.6% to 3.7%.² Participants in ACAS had a perioperative rate of stroke or death of 2.7% overall (1.7% for men and 3.6% for women). In ACST, the perioperative rate of stroke or death was 3.1% overall but was higher for women (3.7%) than for men (2.4%). The observational studies reporting perioperative nonfatal myocardial infarctions showed a rate of approximately 0.7% to 1.1%^8-10 Patients with more comorbid conditions had a rate of nonfatal myocardial infarction up to 3.3%.⁹ The rate of nonfatal perioperative myocardial infarction reported for the surgical group in the RCTs varied from 0.6% to 1.9%. Two Medicare-based studies found variation in perioperative stroke and death among 10 states.^11,12 In the first study, the statewide rates ranged from 2.3% to 6.7%; a follow-up study for the same 10 states found similar results as in 2001, with rates ranging from 1.4% to 6.0%.

Estimate of the Magnitude of Net Benefit

In patients and surgeons similar to those in the RCTs, treatment with carotid endarterectomy for asymptomatic CAS can result in a net absolute reduction in stroke rates—approximately 5% over 5 to 6 years (about 2.5% absolute risk reduction for disabling strokes). The number needed to treat for 5 years to prevent 1 stroke is about 20 (number needed to treat to prevent 1 disabling stroke is about 40). This benefit has been shown in selected patients with selected surgeons, and must be weighed against a small increase in nonfatal myocardial infarctions. The net benefit for carotid endarterectomy largely depends on people surviving the perioperative period without complications and living for 5 years. The 2 RCTs that found a benefit to surgery compared with medical management had 30-day perioperative rates of stroke and death of 2.7% to 3.1% and some large observational studies have shown higher rates.

If ultrasonography screening were followed by magnetic resonance angiography confirmation, about 23 strokes would be prevented over 5 years by screening 100,000 people with a prevalence of CAS of 1%. Thus, about 4,348 people would need to undergo screening to prevent 1 stroke (number needed to screen) after 5 years. Twice this number (8,696) would need to be screened to prevent 1 disabling stroke.

How Does the Evidence Fit with Biological Understanding?

The medical treatment group in the RCTs was poorly defined and probably did not include intensive blood pressure and lipid control, which is standard practice today. It is difficult to determine what effect current standard medical therapy would have on overall benefit from carotid endarterectomy. The Kaplan-Meier curves in ACST cross from net harm to net benefit at about 1.5 years after carotid endarterectomy for men and at nearly 3 years after carotid endarterectomy for women^13-17 The average follow-up time in ACAS and ACST was 2.7 and 3.4 years, respectively; the estimated survival beyond the actual follow-up time may not be applicable in this situation. It is possible that the benefit from carotid endarterectomy is limited to a specific interval and does not continue unabated into the future. Thus, the actual (not projected) risk reduction for carotid endarterectomy over 5 to 10 years is still uncertain.

Although this report did not review the evidence on medical treatment, accepted medical strategies to prevent stroke are available. Until research addresses the gaps in the evidence that screening and treatment with carotid endarterectomy provides overall benefits to the general population, clinicians' efforts might be more practically focused on optimizing medical management of risk factors of stroke.

In 2006, the American Heart Association/American Stroke Association did not recommend screening the general population for asymptomatic carotid stenosis.¹⁸ The American Society of Neuroimaging released recommendations in 2007 that also recommended against screening in unselected populations, but advised that screening of adults age 65 years or older with 3 or more cardiovascular risk factors should be considered.¹⁹ In 2007, the Society for Vascular Surgery recommended ultrasonography screening for individuals age 55 years or older with cardiovascular risk factors, such as a history of hypertension, diabetes mellitus, smoking, hypercholesterolemia, or known cardiovascular disease.²⁰

Members of the U.S. Preventive Services Task Force are* Ned Calonge, MD, MPH, Chair, USPSTF (Chief Medical Officer and State Epidemiologist, Colorado Department of Public Health and Environment, Denver, Colorado); Diana B. Petitti, MD, MPH, Vice-chair, USPSTF (Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Sierra Madre, California); Thomas G. DeWitt, MD (Carl Weihl Professor of Pediatrics and Director of the Division of General and Community Pediatrics, Department of Pediatrics, Children's Hospital Medical Center, Cincinnati, Ohio); Leon Gordis, MD, MPH, DrPH (Professor, Epidemiology Department, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland); Kimberly D. Gregory, MD, MPH (Director, Women's Health Services Research and Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, Cedars-Sinai Medical Center, Los Angeles, California); Russell Harris, MD, MPH (Professor of Medicine, Sheps Center for Health Services Research, University of North Carolina School of Medicine, Chapel Hill, North Carolina); Kenneth W. Kizer, MD, MPH (President and CEO, National Quality Forum, Washington, DC); Michael L. LeFevre, MD, MSPH (Professor, Department of Family and Community Medicine, University of Missouri School of Medicine, Columbia, Missouri); Carol Loveland-Cherry, PhD, RN (Executive Associate Dean, Office of Academic Affairs, University of Michigan School of Nursing, Ann Arbor, Michigan); Lucy N. Marion, PhD, RN (Dean and Professor, School of Nursing, Medical College of Georgia, Augusta, Georgia); Virginia A. Moyer, MD, MPH (Professor, Department of Pediatrics, University of Texas Health Science Center, Houston, Texas); Judith K. Ockene, PhD (Professor of Medicine and Chief of Division of Preventive and Behavioral Medicine, University of Massachusetts Medical School, Worcester, Massachusetts); George F. Sawaya, MD (Associate Professor, Department of Obstetrics, Gynecology, and Reproductive Sciences and Department of Epidemiology and Biostatistics, University of California, San Francisco, California); Albert L. Siu, MD, MSPH (Professor and Chairman, Brookdale Department of Geriatrics and Adult Development, Mount Sinai Medical Center, New York, New York); Steven M. Teutsch, MD, MPH (Executive Director, Outcomes Research and Management, Merck & Company, Inc., West Point, Pennsylvania);** and Barbara P. Yawn, MD, MSPH, MSc (Department of Research, Olmsted Medical Center, Rochester, MN).

*Members of the Task Force at the time this recommendation was finalized. For a list of current Task Force members, go to https://www.uspreventiveservicestaskforce.org/Page/Name/our-members.

**Dr. Teutsch was recused from the discussion and vote on this issue.

Disclaimer: Recommendations made by the USPSTF are independent of the U.S. government. They should not be construed as an official position of the Agency for Healthcare Research and Quality or the U.S. Department of Health and Human Services.

This document is in the public domain within the United States.

Requests for linking or to incorporate content in electronic resources should be sent via the USPSTF contact form.

Source: U.S. Preventive Services Task Force. Screening for carotid artery stenosis: U.S. Preventive Services Task Force recommendation statement. Ann Intern Med 2007;147:854-859..

AHRQ Publication No. 08-05102-EF-2